If I'm understanding this correctly, colorbox handles "popup" images in an album and also the slideshow.

Regardless of whether I enlarge a single image or choose the slideshow, I have to click the X close button two times for the image (layer) to close.

Is this possibly a conflict of settings or ??

My Install Specs ---------------------------
Zenphoto version 1.4.1.6 [8326] (Official Build)
Current gallery theme: zpmasonry_v1.4.1
PHP version: 5.3.8
MySQL version: 5.0.92

Excellent, that did it. Thanks ZEP for the clarification.